2016年10月1日 星期六




謝孟樵 Meng-Chiao Hsieh       


電子信箱 E-mail:


嘉義長庚紀念醫院大腸直腸肛門外科 助理教授級主治醫師
Assistant Professor of Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan

辦公室地址Office Address:

61363 嘉義縣朴子市嘉朴路西段6 嘉義長庚紀念醫院
No 6, Sec West, Chia-Pu Rd, Puzih, Chiayi County 61363, Taiwan

學經歷Academic Appointment:

19999月至20056月 Sep. 1999-Jun. 2005
Medicine, Taipei Medical University, Taipei, Taiwan.

20056月至20065月 Jun. 2005-Mar.2006
Internship, Taipei Medical University Hospital and Wan Fang Hospital.

20068月至20087月 Aug. 2006-Jul. 2008
Residency of Surgery, Chang Gung Memorial Hospital Linko Branch, Taoyuan, Taiwan
Residency of Surgery, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan

20088月至20127月 Aug. 2008-Jul. 2012
嘉義長庚紀念醫院大腸直腸肛門外科 總住院醫師
Chief Resident of Colorectal Surgery, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan

20128月至20166月 Aug. 2012-Jun. 2016
嘉義長庚紀念醫院大腸直腸肛門外科 一般級主治醫師
Attending Physician of Colorectal Surgery, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan

201212月至20131月 Dec. 2012-Jan. 2013
日本國立癌症研究中心中央醫院 內視鏡科 短期臨床研究員
Clinical Fellowships, Department of Endoscopy, Gastrointestinal Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

20167月至今 Jul. 2016-Now
嘉義長庚紀念醫院大腸直腸肛門外科 助理教授級主治醫師
Assistant Professor of Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan

執業執照Professional Affiliations:

Taiwan Medical AssociationBoard No.: 039907
Taiwan Surgery Association Board No.: 006136
Society of Colon and Rectal Surgeon, TaiwanBoard No.: 329
Taiwan Society of Critical Care MedicineBoard No.: 02738
Advanced Trauma Life Support® Student CourseBoard No.: 1010714


Silver Medal, 15th Health Quality Improvement Competition (HQIC) Evidence-based Medicine Clinical Group 

Bronze Medal, 16th Health Quality Improvement Competition (HQIC) Evidence-based Medicine Elite Group 

Publications (論文發表)

1. Chen CH, Hsieh MC, Lai CC, Yeh YC, Chen JS, Hsieh PS, Chiang JM, Tsai WS, Tang RP, Cangchien CR, Wang JY  Lead time of carcinoembryonic antigen elevation in the postoperative follow-up of colorectal cancer did not affect the survival rate after recurrence   Int J Colorectal Dis 2010 ;25(5):567-71. DOI: 10.1007/s00384-010-0889-6. 2015 IF: 2.449

2. Hsieh MC, Chin CC, Huang WS, Yeh CH, Kuo YH, Chen JS, Wang JY Risk Factors and Postoperative Morbidities in Colon Cancer Patients with Preoperative Hypoalbuminemia  
J Soc Colon Rectal Surgeon (Taiwan) 2012;23:6-12. DOI: 10.6312/SCRSTW.2012.23(1).10012.

3. Huang CY, Chin CC, Hsieh MC, Kuo YH, Huang WS, Yeh CH, Chen JS, Tang RP, Wang JY. The Relationship between the Presentation of Hematochezia and Colon Cancer. J Soc Colon Rectal Surgeon (Taiwan) 2012;23:160-167. DOI: 10.6312/SCRSTW.2012.23(4).10113.

4. Hsieh MC*, Peng KT*, Hsu WH, Li YY, Yeh CH Anterior ilioinguinal incision for drainage of high-located perianal abscess. Tech Coloproctol 2013;17:455-458. DOI: 10.1007/s10151-012-0902-x. *Co-first author. 2015 IF: 2.320

5. Shen CH, Tung SY, Huang WS, Lu CC, Lee KC, Hsieh YY, Chang PJ, Liang HF, Chen JH, Lin TH, Hsieh MC, Kuo HC. Exploring the effects of tert-butylhydroperoxide induced liver injury using proteomic approach. Toxicology. 2014;316:61-70. DOI: 10.1016/j.tox.2013.12.007. 2015 IF: 3.817

6. Hsieh YY, Shen CH, Huang WS, Chin CC, Kuo YH, Hsieh MC, Yu HR, Chang TS, Lin TH, Chiu YW, Chen CN, Kuo HC, Tung SY. Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/ NFκB signaling pathway in gastric cancer cells. J Biomed Sci. 2014;21:59. DOI: 10.1186/1423-0127-21-59. 2015 IF: 2.935

7. Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014;15:15073-15089. DOI: 10.3390/ijms150915073. 2015 IF: 3.257

8. Chin CC, Chen CN, Kuo HC, Shi CS, Hsieh MC, Kuo YH, Tung SY, Lee KF, Huang WS. Interleukin-17 induces CC chemokine receptor 6 expression and cell migration in colorectal cancer cells. J Cell Physiol. 2015;230:1430-1437. DOI: 10.1002/jcp.24796. 2015 IF: 4.155

9. Hsieh MC, Kuo LT, Chi CC, Huang WS, Chin CC. Pursestring Closure versus Conventional Primary Closure Following Stoma Reversal to Reduce Surgical Site Infection Rate: A Meta-analysis of Randomized Controlled Trials. Dis Colon Rectum. 2015;58: 808-815. DOI: 10.1097/DCR.0000000000000401. 2014 IF: 3.749

10. Hou CP, Lin YH, Hsieh MC, Chen CL, Chang PL, Huang YC, Tsui KH. Identifying the variables associated with pain during transrectal ultrasonography of the prostate. Patient Prefer Adherence. 2015;9:1207–1212. DOI: 10.2147/PPA.S83073. 2015 IF: 1.718

11. Hsieh MC, Chen CJ, Huang WS. McKittrick-Wheelock Syndrome. Clin Gastroenterol Hepatol. 2016;14:e41–e42. DOI: 10.1016/j.cgh.2015.09.001. 2015 IF: 7.896

12. Kuo HC, Lu CC, Shen CH, Tung SY, Hsieh MC, Lee KC, Lee LY, Chen CC, Teng CC, Huang WS, Chen TC, Lee KF. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med. 2016;14:78. DOI: 10.1186/s12967-016-0831-y. 2015 IF: 3.93

13. Lu CC, Huang WS, Lee KF, Lee KC, Hsieh MC, Huang CY, Lee LY, Lee BO, Teng CC, Shen CH, Tung SY, Kuo HC. Inhibitory effect of Erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21. J Funct Foods. 2016;21:474-484. 2015 IF: 3.574

14. Hsieh MC, Huang WS, Chin CC, Kuo YH, Peng KT. Drainage of a complicated high perianal abscess: a bilateral ilioinguinal approach. Tech Coloproctol. 2016; 20:595-596. DOI: 10.1007/s10151-016-1480-0. 2015 IF: 2.320

15. Yeh CY, Jao SW, Chen JS, Fan CW, Chen HH, Hsieh PS, Wu CC, Lee CC, Kuo YH, Hsieh MC, Huang WS, Chung YC, Liou TY, Chiu HH, Tseng WK, Lee KC, Wang JY. Sebacoyl Dinalbuphine Ester Extended-release Injection for Long-acting Analgesia: A Multicenter, Randomized, Double Blind, and Placebo-controlled Study in Hemorrhoidectomy Patients. J Clin Pain. 2016 Aug 11. [Epub ahead of print] DOI: 10.1097/AJP.0000000000000417 2015 IF: 2.703

16. Hsieh MC*, Huang WS*, Huang CY, Kuo YH, Tung SY, Shen CH, Hsieh YY, Teng CC, Lee KF, Chen TC, Lee KC, Kuo HC. The Association of CXC Receptor 4 mediated signaling pathway with oxaliplatin-resistant human colorectal cancer cells. PLoS ONE. 2016; 11(9): e0159927. *Co-first author DOI: 10.1371/journal.pone.0159927 2015 IF: 3.057

17. Lee KC, Kuo HC2, Shen CH, Lu CC, Huang WS, Hsieh MC, Huang CY, Kuo YH, Hsieh YY, Teng CC, Lee LY, Tung SY. A proteomics approach to identifying novel protein targets involved in erinacine A mediated inhibition of colorectal cancer cells' aggressiveness. J Cell Mol Med. 2016; [Epub ahead of print] DOI: 10.1111/jcmm.13004. 2015 IF: 4.938

18. Kuan FC, Lai CH, Ku HY, Wu CF, Hsieh MC, Liu TW, Yeh CY, Lee KD. The survival impact of delayed surgery and adjuvant chemotherapy on stage II/III rectal cancer with pathological complete response after neoadjuvant chemoradiation. Int J Cancer. 2016 DOI: 10.1002/ijc.30562. 2015 IF: 5.531

19. Huang WS, Kuo YH, Kuo HC, Hsieh MC, Huang CY, Lee KC, Lee KF, Shen CH, Tung SY, Teng CC. CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PLoS One. 2017; 12(1): e0168989. DOI: 10.1371/journal.pone.0168989. 2015 IF: 3.057

20. Kuo YH, Huang CY, Chen CJ, Hsu CH, Chuang HC, Lee TH, Hsieh MC, Huang WS, Chien CC. Impact of KRAS mutation on second-line oxaliplatin-based (FOLFOX-6) chemotherapy for metastatic colorectal cancer. J Soc Colon Rectal Surgeon (Taiwan) 2017; 28:34-42. DOI: 10.6312/SCRSTW.2017.28(1).10530.

21. Wang TY, Chen CY, Lu CH, Chen MC, Lee LW, Hsieh MC, Chen CJ, Yu CM, Chuang HC, Liao TT, Tseng CW, Huang WS. Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy: Preliminary Results of a Multi-Disciplinary Teamwork Model in Asia. Int J Hyperthermia. 2017; 23: 1-8 DOI: 10.1080/02656736.2017.1337238  2015 IF: 3.361

22. Kuo HC, Kuo YR, Lee KF, Hsieh MC, Huang CY, Hsieh YY, Lee KC, Kuo HL, Lee LY, Chen WP, Chen CC, Tung SY. A Comparative Proteomic Analysis of Erinacine A's Inhibition of Gastric Cancer Cell Viability and Invasiveness. Cell Physiol Biochem. 2017; 43: 195-208. DOI: 10.1159/000480338. 2015 IF: 5.104

23. Hsieh MC, Wu CF, Chen CW, Shi CS, Huang WS, Kuan FC. Hypomagnesemia and clinical benefits of anti-EGFR monoclonal antibodies in wild-type KRAS metastatic colorectal cancer: a systematic review and meta-analysis. Sci Rep. 2018 Feb 1; 8: 2047. DOI: 10.1038/s41598-018-19835-8. 2016 IF: 4.259

24. Shen CH, Tung SY, Huang WS, Lee KF, Hsieh YY, Hsieh MC, Chen CN, Kuo HC. Comparative Proteomic Identification of Protein Disulphide Isomerase A6 Associated with Tert-Butylhydroperoxide-Induced Liver Injury in Rat Hepatocytes. Cell Physiol Biochem. 2018; 45: 1915-1926. DOI: 10.1159/000487968. 2016 IF: 5.5

25. Huang WS, Huang CY, Hsieh MC, Tung SY, Shen CH, Hsieh YY, Tenge CC, Lee KC, Lee KF, Kuo HC. Expression of PRDX6 Correlates with Migration and Invasiveness of Colorectal Cancer Cells. Cell Physiol Biochem. 2018;51: 2616-2630. DOI: 10.1159/000495934. 2016 IF: 5.5

26. Sun CY, Hsieh MC, Kuo LM, Chen CH, Huang YI, Huang WS. Single-incision Laparoscopic Surgery Using a Transumbilical Glove-port for Synchronous Colectomy and Hepatectomy: A Preliminary Experience in 9 Patients. J Soc Colon Rectal Surgeon (Taiwan). 2019;30; 36-44. DOI: 10.6312/SCRSTW.201903_30(1).10715

27. Lee KY, Lee KF, Tung SY, Huang WS, Lee LY, Chen WP, Chen CC, Teng CC, Shen CH, Hsieh MC, Kuo HC. Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation. Front Pharmacol. 2019, Oct 1x; 10: 117x DOI: 10.3389/fphar.2019.01174

28. Lee KF, Tung SY, Teng CC, Shen CH, Hsieh MC, Huang CY, Lee KC, Lee LY, Chen WP, Chen CC, Huang WS, Kuo HC. Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson’s Disease. Antioxidants. 2020;9:137. DOI:10.3390/antiox9020137

29. Hsieh MC, Lai CH, Kuo YH, Chin CC, Huang WS. Neoadjuvant Short-Course Radiotherapy or Concurrent Chemoradiotherapy Followed by Radical Colectomy in Locally Advanced Colon Cancer Patients. J Soc Colon Rectal Surgeon (Taiwan). 2020;31:123-133. DOI:10.6312/SCRSTW.202009_31(3).10833

30.  Hsieh MC, Lee TH, Huang WS. Chronic Nonhealing Colonic Ulcer. Clin Gastroenterol Hepatol. 2021 Jun;19(6):e59. DOI: 10.1016/j.cgh.2020.05.050.

31. Teng CC, Tung SY, Lee KC, Lee KF, Huang WS, Shen CH, Hsieh MC, Huang CY, Sheen JM, Kuo HC. Novel regulator role of CIL-102 in the epigenetic modification of TNFR1/TRAIL to induce cell apoptosis in human gastric cancer. Food Chem Toxicol. 2021 Jan;147:111856. DOI: 10.1016/j.fct.2020.111856.

32. Luan CW, Yang HY, Tsai YT, Hsieh MC, Chou HH, Chen KS. Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis. Diagnostics (Basel). 2021;11:403. DOI: 10.3390/diagnostics11030403.

33. Tung SY , Lee KC , Lee KF , Yang YL , Huang WS , Lee LY , Chen WP , Chen CC , Teng CC , Shen CH , Hsieh MC , Huang CY , Sheen JM , Kuo HC . Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL. Food Funct. 2021;12:3455-3468. DOI: 10.1039/d0fo03089a.

34. Cheng KC, Kuo HC, Hsieh MC, Huang CY, Teng CC, Tung SY, Shen CH, Lee KF, Yang YL, Lee KC. Identification of Two Novel CIL-102 Upregulations of ERP29 and FUMH to Inhibit the Migration and Invasiveness of Colorectal Cancer Cells by Using the Proteomic Approach. Biomolecules. 2021;11:1280. DOI: 10.3390/biom11091280.

35. Huang CY, Huang WS, Chin CC, Kuo YH, Hsieh MC, Ho KC. Risk Factors for Mortality in Fournier's Gangrene: Necrotizing Fasciitis in Perineum and Perianal Region, a Single-hospital Experience. J Soc Colon Rectal Surgeon (Taiwan). 2021;32:97-104. DOI: 10.6312/SCRSTW.202109_32(3).11005

36. Luan CW, Chen MY, Yan AZ, Tsai YT, Hsieh MC, Yang HY, Chou HH. Complications associated with irradiated homologous costal cartilage use in rhinoplasty: A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg. 2022;75:2359-2367. DOI: 10.1016/j.bjps.2022.02.026.

37. Huang CY, Lee KC, Tung SY, Huang WS, Teng CC, Lee KF, Kuo HC, Hsieh MC. 2D-DIGE-MS Proteomics Approaches for Identification of Gelsolin and Peroxiredoxin 4 with Lymph Node Metastasis in Colorectal Cancer. Cancers (Basel). 2022;14:3189. DOI: 10.3390/cancers14133189.